Which tissue serves as a good positive control for glycogen demonstration in PAS?

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Multiple Choice

Which tissue serves as a good positive control for glycogen demonstration in PAS?

Explanation:
Periodic acid–Schiff staining highlights glycogen as magenta, so you want a tissue with a lot of glycogen to confirm the stain is working. The liver stores large amounts of glycogen in hepatocytes, giving a strong, uniform PAS signal, which makes it the best positive control among the options. Heart contains some glycogen but far less; spleen and lung have little glycogen and would not reliably demonstrate the stain. So, liver is the appropriate positive control for glycogen demonstration in PAS.

Periodic acid–Schiff staining highlights glycogen as magenta, so you want a tissue with a lot of glycogen to confirm the stain is working. The liver stores large amounts of glycogen in hepatocytes, giving a strong, uniform PAS signal, which makes it the best positive control among the options. Heart contains some glycogen but far less; spleen and lung have little glycogen and would not reliably demonstrate the stain. So, liver is the appropriate positive control for glycogen demonstration in PAS.

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