What is the purpose of acetic acid in Zenker solution?

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Multiple Choice

What is the purpose of acetic acid in Zenker solution?

Explanation:
Acetic acid in Zenker solution is included to lyse red blood cells. The acidic component helps break down erythrocyte membranes, reducing red cell interference so tissue details stain more clearly. Zenker is a mercuric chloride–based fixative that preserves tissue by protein precipitation, but the acetic acid specifically enhances penetration and removes RBCs that could obscure cellular morphology. It is not used to decalcify bone or primarily to stabilize proteins, and while it does influence acidity, its notable practical role in this fixative is RBC lysis.

Acetic acid in Zenker solution is included to lyse red blood cells. The acidic component helps break down erythrocyte membranes, reducing red cell interference so tissue details stain more clearly. Zenker is a mercuric chloride–based fixative that preserves tissue by protein precipitation, but the acetic acid specifically enhances penetration and removes RBCs that could obscure cellular morphology. It is not used to decalcify bone or primarily to stabilize proteins, and while it does influence acidity, its notable practical role in this fixative is RBC lysis.

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