The blue staining of the cytoplasm in the image is due to which cellular structure?

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Multiple Choice

The blue staining of the cytoplasm in the image is due to which cellular structure?

Explanation:
Blue, basophilic cytoplasm in routine H&E sections points to RNA-rich structures. The rough endoplasmic reticulum is studded with ribosomes, which contain ribosomal RNA that binds hematoxylin and stains blue/purple. This basophilia reflects active protein synthesis happening on the RER, which is why cells with abundant RER (like secretory cells) show a blue cytoplasm around the nucleus. Mitochondria typically stain pink with eosin in standard slides, Golgi tends to be relatively pale, and lysosomes don’t produce strong blue cytoplasmic staining in routine staining.

Blue, basophilic cytoplasm in routine H&E sections points to RNA-rich structures. The rough endoplasmic reticulum is studded with ribosomes, which contain ribosomal RNA that binds hematoxylin and stains blue/purple. This basophilia reflects active protein synthesis happening on the RER, which is why cells with abundant RER (like secretory cells) show a blue cytoplasm around the nucleus. Mitochondria typically stain pink with eosin in standard slides, Golgi tends to be relatively pale, and lysosomes don’t produce strong blue cytoplasmic staining in routine staining.

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