Paraffin will dissolve fat out during processing.

• A. True
• B. False
• C. Sometimes
• D. Never

Answer: (A)

Lipids are removed during tissue processing by the clearing solvent (such as xylene or toluene) during dehydration and clearing steps, not by the paraffin itself. Paraffin is used to infiltrate and embed the tissue after fats have already been dissolved and removed by those solvents. Because paraffin does not dissolve fats, the statement is false. In paraffin-embedded sections, lipids are typically gone; to study fats specifically, one would use frozen sections or special lipid stains that preserve lipids, since the standard paraffin processing removes them.