Non-coagulant fixatives include which of the following as an example?

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Multiple Choice

Non-coagulant fixatives include which of the following as an example?

Explanation:
Non-coagulant fixatives preserve tissue architecture by cross-linking proteins rather than precipitating them. Formaldehyde-based fixatives do this by forming methylene bridges between amino groups, stabilizing structures without creating a solid coagulum. Using a neutral buffer helps maintain a stable pH, reducing artifacts. Therefore, 10% neutral buffered formalin is the example of a non-coagulant fixative in the list. The other options—ethanol, zinc formalin, and B5 fixative—act as coagulative fixatives, causing protein precipitation or harsh dehydration that denatures and shrinks tissue.

Non-coagulant fixatives preserve tissue architecture by cross-linking proteins rather than precipitating them. Formaldehyde-based fixatives do this by forming methylene bridges between amino groups, stabilizing structures without creating a solid coagulum. Using a neutral buffer helps maintain a stable pH, reducing artifacts.

Therefore, 10% neutral buffered formalin is the example of a non-coagulant fixative in the list. The other options—ethanol, zinc formalin, and B5 fixative—act as coagulative fixatives, causing protein precipitation or harsh dehydration that denatures and shrinks tissue.

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