Nissl substance is composed of clumps of DNA.

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Multiple Choice

Nissl substance is composed of clumps of DNA.

Explanation:
The main idea is that Nissl substance reflects RNA-rich cytoplasmic material, not DNA. Nissl bodies are aggregates of rough endoplasmic reticulum studded with ribosomes, so they’re high in ribosomal RNA. Basic dyes in Nissl staining bind to this RNA, giving the characteristic basophilic granules in neuron cell bodies. DNA, on the other hand, is confined to the nucleus (and mitochondrial genomes) and is not organized into the cytoplasmic clumps called Nissl bodies. So the statement is false because Nissl substance is RNA-rich ribosomes on rough ER, not DNA.

The main idea is that Nissl substance reflects RNA-rich cytoplasmic material, not DNA. Nissl bodies are aggregates of rough endoplasmic reticulum studded with ribosomes, so they’re high in ribosomal RNA. Basic dyes in Nissl staining bind to this RNA, giving the characteristic basophilic granules in neuron cell bodies. DNA, on the other hand, is confined to the nucleus (and mitochondrial genomes) and is not organized into the cytoplasmic clumps called Nissl bodies. So the statement is false because Nissl substance is RNA-rich ribosomes on rough ER, not DNA.

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