Carnoy solution is the best fixative for adipose tissue.

• A. True
• B. False
• C. Adipose only
• D. Mast cells only

Answer: (B)

Adipose tissue is rich in lipids, and fixatives that contain chloroform and strong organic solvents (like Carnoy’s solution) dissolve fats. Because the fats are extracted during fixation and subsequent processing, the adipose cells lose their lipid content and diameters can shrink or appear artifactsed, making Carnoy’s solution unsuitable for preserving fat tissue. In routine paraffin embedding, 10% neutral buffered formalin is preferred to maintain overall tissue morphology without aggressively dissolving lipids; if the goal is to visualize lipids themselves, frozen sections with lipid stains (or fixatives like osmium tetroxide for specific applications) are used. So the statement is not correct.