A fixative stops autolysis and putrefaction.

• A. True
• B. False
• C. Not enough information
• D. Not applicable

Answer: (A)

Fixation preserves tissue by inactivating enzymes that would digest cells (autolysis) and by inhibiting microbial activity that drives decomposition (putrefaction). Aldehyde fixatives, like formalin, cross-link proteins and denature enzymes, effectively stopping enzymatic degradation. They also create conditions that hinder bacteria, helping to prevent decay. Prompt and adequate penetration of the fixative is essential; if fixation is delayed or uneven, some autolysis or putrefaction can still begin in untreated areas.